Event-Related Potentials and executive control deficits in major depression: evidence from the Attention Network Test.

ABSTRACT:

Objective

Behavioral and neurological studies suggest that major depressive disorder (MDD) is associated with pervasive deficits in executive control of attention. Research using Event-Related Potentials (ERPs) to investigate attentional impairments in depression has provided mixed results. The current study aimed to clarify abnormalities in ERPs associated with depression through use of the Attention Network Test (ANT) which assesses efficiency of three fundamental brain networks: executive control, alerting, and orienting.

Methods

Participants were 93 volunteers. We compared ERP amplitudes in healthy, subsyndromal depression, and MDD groups (31 participants per group) during performance of an extended-duration version of the ANT.

Results

Both N100 and P300 ERP ampli

SUBMITTER: Kustubayeva A 

PROVIDER: S-EPMC12856934 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature