Impact of HIV status on overall survival in head and neck cancers by anatomical site and stage: A multi-center cohort study.

ABSTRACT:

Objectives

People with human immunodeficiency virus (PWH) are at higher risk for head and neck cancer (HNC) than people without HIV (PWoH), but data on the survival effect of HIV are scarce. The objective is to compare survival for PWH vs. PWoH diagnosed with HNC, stratified by anatomical site and cancer stage.

Materials and methods

The multi-institutional U.S.-based retrospective analysis included HNC patients (296 PWH and 29,875 PWoH) diagnosed between 2008 and 2020. Statistical analysis reported 5-year overall survival and hazard ratios (HR) for all-cause mortality by HIV infection and CD4 counts for oropharyngeal cancer (OPC), oral cavity cancer (OC), and laryngeal and hypopharyngeal cancers (LHPC); with additional analysis stratified by HPV status and stage (I-IVB).

SUBMITTER: Malgave DS 

PROVIDER: S-EPMC12856976 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature