Performance evaluation of the automated haematology analyzer XN-31 for malaria diagnosis in Plasmodium vivax-dominant regions of Thailand.

ABSTRACT:

Background

The innovative automated haematology analyzer XN-31 has demonstrated comparable or, in some settings, superior performance to microscopy and rapid diagnostic tests (RDTs), and good concordance with polymerase chain reaction (PCR) in various endemic areas, particularly where Plasmodium falciparum is prevalent. The XN-31 applies the principle of flow cytometry to measure cell size and nucleic acid content to generate a two-dimensional cytogram in approximately one minute. This technique identifies P. falciparum and other species and provides % parasitaemia (MI-RBC%). This study evaluated the diagnostic performance of the XN-31 in Thailand, where Plasmodium vivax is predominant.

Methods

From November 2019 to June 2022, 349 patients suspected of having malaria were en

SUBMITTER: Kawaguchi M 

PROVIDER: S-EPMC12857124 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature