ABI5-binding proteins are substrates of key components in the ABA core signaling pathway affecting seeds.

ABSTRACT: The central components of the ABA core signaling pathway are families of receptors, clade A type 2C protein phosphatases (PP2Cs), SNF1-related protein kinases (SnRK2s), and diverse sets of proteins regulated by phosphorylation via these kinases, including basic leucine zipper (bZIP) transcription factors such as ABA-INSENSITIVE(ABI)5. The larger network of ABA signaling factors includes additional kinases and E3 ligases that modify these components to affect their activity and stability. ABI5-binding proteins (AFPs) are negative regulators of ABA response, and this study shows that Arabidopsis thaliana AFPs interact with specific family members of all components of this pathway and are substrates for SnRK2s and PP2Cs. AFPs also interact with subsets of MAP kinases (MPKs) and 14-3-3 protein

SUBMITTER: Lynch TJ 

PROVIDER: S-EPMC12857203 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature