Association between plasma phosphate/pyrophosphate ratio and computed tomography-derived aortic valve calcification score in an unselected cohort of cardiovascular patients.

ABSTRACT:

Aims

Inorganic pyrophosphate (PPi) is an endogenous inhibitor of soft tissue calcification. A disturbed equilibrium between pro- and anti-mineralization agents, like extracellular phosphate (Pi) and PPi, has been implicated in the mechanism of aortic valve calcification (AVC). We aimed to investigate the association of the plasma PPi concentration and Pi/PPi ratio with the degree AVC in cardiovascular patients.

Methods and results

One hundred and fifty-four patients referred for cardiac computed tomography (CT), including 43 individuals with severe aortic stenosis, were prospectively enrolled. The aortic valve calcium score (AVCS) was measured on non-contrast CT images. Plasma PPi level was determined enzymatically. Of the entire population (age: 67 ± 12 years, 42.5% female)

SUBMITTER: Juhasz D 

PROVIDER: S-EPMC12857225 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature