Amyloid β alters vascular Ca_V1.2 channel spatiotemporal properties.

ABSTRACT: A hallmark of Alzheimer's disease is reduced cerebral blood flow, which appears to occur early in disease progression and has been associated with amyloid β (Aβ) accumulation. Cerebral artery diameter is regulated by calcium influx via voltage-gated L-type Ca_V1.2 channels, which contribute to arterial myocyte contractility. The potential effects of Aβ on vascular Ca_V1.2 channels remain unclear. To address this knowledge gap, we test the hypothesis that Aβ alters vascular Ca_V1.2 channel spatiotemporal properties. Using freshly dissected cerebral arteries and arterial myocytes from wild-type (WT) mice, super-resolution imaging revealed that Aβ_1-42, but not Aβ_1-40, increased the clustering of Ca_V1.2 channels in male but not fem

SUBMITTER: Taylor JL 

PROVIDER: S-EPMC12857231 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature