Escape from cell uptake: Drug-Free cancer therapeutics regulated by hydrophobicity and negative charge.

ABSTRACT: Self-aggregation and inducing cell membrane disruption in response to tumor microenvironment-stimuli is expected to be a promising approach for cancer treatment, but is limited by its insufficient stimuli-responsive cytotoxicity due to a lack of in-depth understanding of molecular characteristics, resulting in low selectivity of cell death induction. In this study, we focused on engineering polymer aggregation in detail to further improve tumor microenvironment-responsive cytotoxicity. PVA-U with grafting degrees (G.D.) of 3 % (PVA-U3), 15 % (PVA-U15), and 25 % (PVA-U25) were synthesized and their aggregation properties cytotoxicity was evaluated. The difference in half maximal inhibitory concentration (IC₅₀) values between pH 7.4 and pH 6.5 for PVA-U15 was 4.3-fold, which was g

SUBMITTER: Moroishi K 

PROVIDER: S-EPMC12857268 | biostudies-literature | 2026 Apr

REPOSITORIES: biostudies-literature