A multifunctional and ROS response CO-gas delivery platform for spinal cord regeneration.

ABSTRACT: Spinal cord injury (SCI) initiates a cascade of pathological events in which neuroinflammation and hypoxia critically impair functional recovery. Although exogenous carbon monoxide (CO) exhibits anti-inflammatory potential, its translation has been hindered by the lack of a safe and effective delivery strategy. Here, we report the development of a multifunctional therapeutic platform (COPH), composed of CO-releasing molecules-401 (CORM-401) as the CO donor, peptide dendrimer nanogels (PDNs) as the carrier, and hyaluronic acid (HA) as a microglia-targeting ligand. COPH selectively accumulates in microglia, where it responds to elevated reactive oxygen species (ROS) by releasing CO and simultaneously scavenging excessive ROS. In vitro and in vivo studies demonstrate that COPH suppresses pro-

SUBMITTER: Huang Z 

PROVIDER: S-EPMC12857284 | biostudies-literature | 2026 Apr

REPOSITORIES: biostudies-literature