Unraveling the neuroprotective mechanisms of elephant black garlic extract against beta amyloid peptide-induced neurotoxicity.

ABSTRACT: Chilean Elephant Black Garlic (Allium ampeloprasum) is a distinctive variety whose biological activity remains largely unexplored. Unlike conventional black garlic derived from Allium sativum, this preparation exhibits a markedly different chemical profile enriched in sulfur-containing metabolites such as 3H-1,2-dithiol-3-thione (D3T) and 4-methyl-1,2,3-trithiolane (TTL). These compounds are rarely detected in traditional black garlic extracts and may underlie the specific protective effects observed in this study. Consequently, the biological actions described here cannot be generalized to other black garlic preparations. We provide the first evidence that Chilean Elephant Black Garlic (BG) confers neuroprotection against the toxicity of soluble oligomers of amyloid-beta (SO

SUBMITTER: Gavilan J 

PROVIDER: S-EPMC12857319 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature