International multicenter retrospective study on pleomorphic rhabdomyosarcoma (P-RMS), a PUSH platform study: outcome of primary localized disease.

ABSTRACT:

Background

The purpose of this study was to report the outcome of primary localized pleomorphic rhabdomyosarcoma (P-RMS).

Patients and methods

Patients with primary localized P-RMS, aged >40 years, and surgically treated with curative intent from January 2013 to December 2023 were enrolled from 25 institutions across 12 countries. Pathological inclusion criteria were predefined by expert pathologists per established World Health Organization guidelines. Primary endpoint was overall survival (OS). Secondary endpoints were disease-free survival (DFS), crude cumulative incidence (CCI) of local recurrence (LR), CCI of distant metastases (DM), post-relapse OS, and post-metastasis OS.

Results

A total of 93 patients were eligible and included in the present study. At a media

SUBMITTER: Giani C 

PROVIDER: S-EPMC12857327 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature