A rare cause of shock in cases of refractory hypotension, hypoproteinaemia and haemoconcentration.

ABSTRACT: This case report describes a woman in her mid-40s of European ancestry presenting with recurrent profound hypotension, hypoproteinaemia and haemoconcentration. She first presented following administration of a Japanese encephalitis vaccine. The initial differential diagnoses included sepsis or an anaphylactic reaction to the vaccine. No evidence of allergy or infection was found during extensive investigation including a lumbar puncture. Following a second similar presentation, she was diagnosed with idiopathic systemic capillary leak syndrome (ISCLS). Her presentation was highly atypical due to the high frequency of episodes encountered (34 over a near 6-year period). A variety of triggers for episodes were identified including COVID-19 infections, influenza infection and vaccinations. We

SUBMITTER: Elhassan O 

PROVIDER: S-EPMC12857328 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature