Abnormal spirometry 1 year after lung transplantation may identify patients at risk for chronic lung allograft dysfunction in a multicenter cohort.

ABSTRACT:

Background

Baseline lung allograft dysfunction (BLAD) is the failure to achieve predicted pulmonary function after lung transplantation. BLAD, as defined by abnormal spirometry at 12 months post-transplant (Spiro12M), has been associated with increased mortality and chronic lung allograft dysfunction (CLAD) in a single-center study. We sought to validate Spiro12M in a prospective multicenter study that included bilateral (BLTx) and single (SLTx) lung recipients.

Methods

The cohort included first lung recipients from 5 North American transplant centers participating in the Clinical Trials in Organ Transplantation-20 study. Abnormal Spiro12M was defined as a percent predicted forced expiratory volume in 1 second (FEV1) or forced vital capacity (FVC) at 12 months post-transplan

SUBMITTER: Graham AR 

PROVIDER: S-EPMC12857350 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature