Dietary urolithin a improves hepatic antioxidant function and laying performance in aging hens via Nrf2 signaling pathway activation.

ABSTRACT: The decline in productivity and increased immune stress associated with hepatic oxidative stress in aging laying hens limit the efficiency of egg production. Urolithin A (UA), a natural metabolite, has been shown to activate the Nrf2 antioxidant pathway in mammals; however, its effects and underlying mechanisms in laying hens remain unclear. This study aimed to systematically evaluate the dose-response effects of dietary UA on the health and production performance of laying hens, with an emphasis on its role in activating the Nrf2 pathway. Fifty (45-week-old) Roman Pink laying hens were randomly assigned to one of five dietary treatments: a basal diet supplemented with 0, 50, 200, 400, or 800 mg/kg UA for 6 weeks. The production performance, organ indices, serum and liver lipid profiles, a

SUBMITTER: Wu L 

PROVIDER: S-EPMC12857355 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature