Phospholipase A₂ products influence the antiplatelet functions of synthetic high-density lipoproteins.

ABSTRACT: Multiple synthetic high-density lipoproteins (sHDLs) have been developed and extensively evaluated in preclinical and clinical trials, with their functionality potentially linked to specific lipid compositions. This study investigates how lipid composition influences sHDL interactions with platelets. We synthesized sHDL particles using ApoA1 mimetic peptide 22A complexed with various lipids (DMPC, POPC, DSPC, DPPC, and SM) differing in chain lengths, saturation levels, and transition temperatures. DMPC sHDL demonstrated superior inhibition of platelet aggregation across multiple agonist concentrations, while POPC sHDL showed limited efficacy only at lower thrombin concentrations. Interestingly, all formulations exhibited similar cholesterol removal abilities, and POPC sHDL demonstrated the

SUBMITTER: Rodriguez A 

PROVIDER: S-EPMC12857358 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature