Protection of goose adiponectin-derived peptide gADP3 on LPS-induced thymus and spleen injury in goose.

ABSTRACT: This study aims to evaluate the protective effects of goose-derived adiponectin peptide gADP3 on Lipopolysaccharide (LPS)-induced damage to goose thymus and spleen. LPS-induced inflammation was induced via intraperitoneal injection, with interventions using gADP3 and AdipoRon (positive control). Pathological changes in thymus and spleen tissues were observed. Levels of biochemical indicators related to inflammation, oxidative stress, and immunity in blood and tissue were measured. Additionally, tissue expression of key factors associated with inflammation, adiponectin receptors, and signaling pathways involved in inflammation and oxidative stress was assessed. The results showed that gADP3 and AdipoRon improved the histology of the thymus and spleen, reduced the infiltration of inflammator

SUBMITTER: Ma B 

PROVIDER: S-EPMC12857376 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature