Mucosal B Cell Expansion and Maturation Contribute to Colitis Pathogenesis.

ABSTRACT:

Background

Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by relapsing and remitting mucosal inflammation of the colon. While active UC mucosa is characterized by dysregulated B cell responses and increased B cell and IgG plasma cell populations, targeting CD20-expressing B cells in UC has proven ineffective.

Methods

We conducted an exploratory single-cell transcriptomic analysis of colonic biopsies obtained from UC patients with (n = 5) or without (n = 5) active inflammation, and non-UC controls (n = 4). To explore whether B cells contribute to colitis severity, we transferred various ratios of spleen-derived naive B cells with CD45RBhigh T cells into severe combined immune deficient mice to induce colitis.

Results

Our analysis identifi

SUBMITTER: Fung ICN 

PROVIDER: S-EPMC12857420 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature