Metagenomic Sequencing Reveals Distinct Gut Microbiome Profiles in Therapy-Naive de Novo Pediatric Inflammatory Bowel Disease.

ABSTRACT:

Background and aims

Microbiome studies reveal distinct microbial differences in inflammatory bowel disease (IBD), indicating its potential role in pathophysiology and as a noninvasive diagnostic biomarker. This study aims to profile the gut microbiome in children with IBD, compared to both healthy controls (HC) and controls with gastrointestinal symptoms (CGI), and to assess the potential of microbiome profiles as noninvasive diagnostic markers for de novo treatment-naïve pediatric IBD, and as early predictive markers for therapy response.

Methods

We analyzed baseline fecal samples and clinical data from 103 therapy-naïve children with IBD, 75 CGI, and 356 age and sex matched HC. Metagenomic sequencing was performed, and prediction models assessed diagnostic potential and pr

SUBMITTER: Vermeer E 

PROVIDER: S-EPMC12857426 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature