Comparative Risk of Serious Infections Associated With Treatment of Inflammatory Bowel Disease.

ABSTRACT:

Background

There is paucity of data on the risk of infection-related hospitalization among inflammatory bowel disease (IBD) patients exposed to newer biologics. Our aim was to assess the overall and comparative risk of infection-related hospitalization, among IBD patients exposed to different IBD medication classes.

Methods

This was a retrospective cohort study of adult IBD patients in the Veterans Health Administration. New initiators of different IBD medication classes were identified, and the primary outcome was infection requiring hospitalization. Survival analysis methods were used to evaluate the association between time-updated IBD medications and these outcomes, adjusted for key confounders.

Results

The cohort included 14 554 IBD patients. There were 3131 infe

SUBMITTER: Khan N 

PROVIDER: S-EPMC12857427 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature