Clinical significance and immune microenvironment association of cuproptosis-related genes in pan-cancer.

ABSTRACT: Recent studies highlight the important roles of cuproptosis in cancer cells. However, the roles of the cuproptosis-related genes (CRGs) in different cancers are still not fully understood. Comprehensive analysis was performed using open-source bioinformatic platforms to disclose the expression profiles, prognostic significance, genomic and epigenetic characteristics, immune microenvironment, and drug sensitivity of CRGs including FDX1, LIAS, LIPT1, DLD, DLAT, PDHA1, PDHB, SLC31A1, MTF1, GLS, CDKN2A, HSPA4 and ATP7B. The colon cancer samples were further obtained to verify the correlation between CDKN2A expression and immune cell infiltration by fluorescence staining. We demonstrated the expression level, methylation and the copy number variant feature, as well as the prognostic significanc

SUBMITTER: Ge X 

PROVIDER: S-EPMC12857452 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature