Sex differences in cerebral pulsatility and damping: A 4D flow MRI study.

ABSTRACT: Cerebral pulsatility is a potential marker of cerebrovascular health, yet little is understood about sex differences in cerebral pulsatility with age, especially within different cerebral arteries. Additionally, cerebral damping can blunt cerebral pulsatility and might decline with age. Therefore, we aimed to identify sex differences in cerebral pulsatility and damping across the adult lifespan. Forty-three young, 67 middle-aged and 54 older adults had cerebral haemodynamics measured in the internal carotid arteries (ICAs), middle cerebral arteries (MCAs) and basilar artery using 4D flow MRI. Cerebral pulsatility index (PI) and damping factor (DF) were calculated. Young females had lower PI than young males in the ICAs (p < 0.05 for both), and middle-aged females had lower PI than middle-a

SUBMITTER: Gaynor-Metzinger SHA 

PROVIDER: S-EPMC12857486 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature