Autoantibodies neutralizing type 1 interferons in two cohorts of people with HIV.

ABSTRACT: Autoantibodies (autoAbs) neutralizing type I interferons (IFN-I) markedly increase the risk of severe manifestations of some viral diseases. The prevalence of autoAbs neutralizing at least one IFN-I, specifically IFN-α2, IFN-β, and IFN-ω, in individuals from the Swiss human immunodeficiency virus 1 (HIV-1) cohort is largely similar to French age-matched healthy controls, with around 1% in adults by age 65 having neutralizing IFN-I autoAbs and rising thereafter. We analyzed samples from Danish individuals with HIV, including antiretroviral therapy (ART) treated (n = 260) and ART-naive (n = 58) individuals, aged 18-79 (mean age 46.6 years, SD ± 11.1 years), and American individuals with HIV, all of whom were ART-naive (n = 292) aged 20-76 (mean age 41.7 years, SD ± 10.1

SUBMITTER: Jensen JA 

PROVIDER: S-EPMC12857536 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature