Phylodynamic reconstruction of H1N1pdm09 influenza virus transmission in Brazil: a decade of evolutionary dynamics.

ABSTRACT: The H1N1pdm09 influenza virus, which emerged in 2009 following a unique reassortment of swine-origin gene segments, rapidly replaced the seasonal H1N1 strain and triggered the first influenza pandemic of the twenty-first century. In Brazil, the virus initially spread through intense community transmission before establishing a pattern of seasonal circulation. However, its long-term evolutionary dynamics in the country remain insufficiently characterized. To address this gap, we conducted a coordinated national genomic surveillance effort focused on the period from 2014 onward, when Brazil began systematic whole-genome sequencing of circulating H1N1pdm09 viruses. Through collaborative sequencing across all five Brazilian macroregions, we generated 597 complete genomes collected between 2014

SUBMITTER: Brcko IC 

PROVIDER: S-EPMC12857685 | biostudies-literature | 2026 Dec

REPOSITORIES: biostudies-literature