Age-Related Germline Landscape of Endometrial Cancer: Focus on Early-Onset Cases.

ABSTRACT:

Purpose

Early-onset endometrial cancer (eoEC) is increasing, and germline drivers may be enriched in younger patients. We sought to define germline pathogenic variants (gPVs) in those with EC by age.

Methods

We identified patients with EC who underwent clinical tumor-normal sequencing from December 2014 to June 2021 and collected clinical variables. Logistic regression models evaluated associations between age at EC diagnosis and presence of gPV, biallelic inactivation, and Lynch Syndrome (LS). Age categories were defined as early-onset (eoEC, EC < 50 years) and late-onset (EC ≥ 70 years) and were compared with those diagnosed ages 50-69 years.

Results

Among 1,625 patients with EC, the median age at diagnosis was 63 (range, 24-96) years. We observed gPV in 28 (16%) of

SUBMITTER: Wang JJ 

PROVIDER: S-EPMC12857754 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature