The Ly6g^high Neutrophil Subset Dictates Breast Cancer Lung Metastasis via CD8⁺ T Cell Death.

ABSTRACT: Background: Lung metastasis is a leading cause of breast cancer (BC)-related mortality, driven by the immunosuppressive traits of the metastatic tumor microenvironment. However, the mechanisms underlying cell-cell crosstalk in shaping immune evasion within the metastatic niche remain poorly defined. Neutrophil extracellular traps (NETs) and their associated proteins, such as cathelicidin, have emerged as key mediators of metastatic regulation in cancer. Here, we aimed to decipher the interaction between a neutrophil subset characterized by high expression of lymphocyte antigen 6 complex locus g (Ly6g^high) and cluster of differentiation 8-positive T lymphocytes (CD8⁺ T cells), mediated via cathelicidin embedded in NETs, as well as their synergistic mechanism and

SUBMITTER: Wang R 

PROVIDER: S-EPMC12857760 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature