Heart rate changes in chronically red cell transfusion-dependent patients-A dose-dependent effect of red cell transfusion: A randomized cross-over trial, interim analysis.

ABSTRACT:

Background

Restrictive red blood cell transfusion strategies are widely recommended for acute anemia but may not adequately address the needs of chronically anemic patients with transfusion-dependent myelodysplastic syndromes or myeloproliferative neoplasms. For these patients with chronic anemia, alleviating symptoms and improving quality of life are key objectives. This study evaluates the impact of additional red blood cell (RBC) transfusions administered alongside standard-of-care transfusions on heart rate, physical activity, quality of life, and cognitive function.

Study design and methods

This interim analysis of a randomized, multicenter, within-subject, cross-over trial evaluated 12 transfusion-dependent patients receiving three transfusion regimens: standard-of-car

SUBMITTER: Tonino RPB 

PROVIDER: S-EPMC12857865 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature