Transfusion-related adverse events in patients with restrictive or liberal transfusion strategy. An analysis of the MINT trial.

ABSTRACT:

Background

The aim of this analysis was to quantify and compare the frequency of transfusion-related adverse events (TRAE) in adult patients with myocardial infarction transfused with a restrictive versus liberal transfusion strategy from the Myocardial Ischemia and Transfusion (MINT) trial.

Study design and methods

Clinical sites reported TRAE. Major TRAE were transfusion-related acute lung injury, transfusion-associated circulatory overload, acute hemolytic transfusion reaction, anaphylactic transfusion reaction, and transfusion-associated sepsis. TRAE rates per transfusion arm per patient and per 100 units of red blood cells (RBC) transfused were calculated.

Results

There were nine site-reported events in the restrictive transfusion arm and 49 events in the liberal

SUBMITTER: Ghafghazi S 

PROVIDER: S-EPMC12857874 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature