Genetic insights into number of long-term conditions and their relationship with lifespan.

ABSTRACT:

Aims

Relationships between the genetic risk for long-term conditions (LTCs) and lifespan have been reported. However, the genetic factors underlying the total number of LTCs an individual has (LTC burden) and their association with lifespan have not been fully investigated. This study aims to investigate the genetics of LTC burden and evaluate its relationship with lifespan.

Methods

A genome-wide association study (GWAS) and a genetic heritability test were conducted on LTC burden using data from 343,868 UK Biobank individuals. Global and local genetic correlations between the LTC burden and parental lifespan were estimated. A polygenic risk score (PRSLTC) for LTC burden was derived from a separate set of 34,339 UK Biobank individuals with records of age at death, who were n

SUBMITTER: Bhak Y 

PROVIDER: S-EPMC12857943 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature