A novel approach for longitudinal analysis of serum biomarkers of joint metabolism and knee injury in military officers.

ABSTRACT:

Purpose

To investigate the longitudinal relationships between serum biomarkers of joint metabolism, knee injury, and Knee Injury and Osteoarthritis Outcome Score (KOOS) using novel methodologies.

Methods

Data were collected from military officers who enrolled as cadets between 2004-2009, with follow-up conducted between 2015-2017. Analyses included 234 officers who had no history of knee ligament/meniscal injury at the time of military academy matriculation, had serum biomarker measurements at matriculation and graduation, demographic data, and KOOS assessment at follow-up. Biomarkers included Collagen Type II (C2C) and Type I and II (C1,2C) collagenase-generated cleavage epitopes, C-terminal propeptide of Type II collagen (CPII), and C- and N-terminal telopeptides of type I

SUBMITTER: Arbeeva L 

PROVIDER: S-EPMC12857958 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature