Drospirenone promotes apoptosis in ectopic but inhibits proliferation in eutopic human endometrial stromal cells.

ABSTRACT:

Background

Endometriosis is a complex gynecological condition characterized by endometrial tissue growing outside the uterus. In many in vitro studies, almost all progestins have indicated the anti-proliferation and apoptosis of endometriotic stromal cells. Drospirenone, a synthetic progestin structurally distinct from traditional progestins, still lacks sufficient data regarding its effects on endometriosis, particularly in terms of antiproliferative and pro-apoptotic activity. This study investigates the antiproliferative effects of drospirenone on eutopic (EU-ESCs) and ectopic human endometrial stromal cells (EC-ESCs), and compare its impact on apoptotic effects in both cell types.

Methods and findings

In the study, paired EU-ESCs and EC-ESCs were obtained from patients d

SUBMITTER: Wongwananuruk T 

PROVIDER: S-EPMC12857992 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature