CDC42-Effector Proteins Regulate Higher Order Structure of Septins Required for CNS Myelin Integrity.

ABSTRACT: The regular structure of CNS myelin requires specialized structural proteins, including septin filaments composed of subunits SEPTIN2, SEPTIN4, SEPTIN7, and SEPTIN8. These filaments scaffold the innermost non-compacted myelin layer; their disruption causes pathological myelin outfoldings. However, the mechanisms that control myelin septin assembly are incompletely understood. We found that loss of CDC42 from oligodendrocytes of adult mice causes myelin pathology including outfoldings, coinciding with depletion of myelin septins and CDC42-effector proteins (CDC42EP1 and CDC42EP2). We thus tested the functional relevance of the latter by deleting both the Cdc42ep1 and Cdc42ep2-genes in oligodendrocytes. We observed myelin outfoldings as a very specific pathology, markedly reduced abundance o

SUBMITTER: Hummert S 

PROVIDER: S-EPMC12858042 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature