Tissue-resident macrophage and dendritic cells drive type I IFN immunity to enteroviruses in the liver.

ABSTRACT: Enteroviruses are major causes of neonatal morbidity and mortality, with echovirus infections commonly associated with severe disease, including acute liver failure. The human neonatal Fc receptor (hFcRn) is the primary receptor for echoviruses, and its expression is required for infection of the liver in mouse models. While type I interferons (IFNs) are known to protect against echovirus-induced disease, the specific innate immune cells responsible for initiating this antiviral signaling in the liver remain undefined. To dissect the relative contributions of type I and type III IFNs in protecting the liver during echovirus infection, we combined in vivo mouse models (expressing hFcRn and deficient in Ifnar1, Ifnlr1, or both) with single cell RNA sequencing (scRNA-seq). This approach enabl

SUBMITTER: Heckenberg E 

PROVIDER: S-EPMC12858076 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature