Causal evidence for a domain-specific role of left superior frontal sulcus in human perceptual decision-making.

ABSTRACT: Humans and animals can flexibly choose their actions based on different information, ranging from objective states of the environment (e.g., apples are bigger than cherries) to subjective preferences (e.g., cherries are tastier than apples). Whether the brain instantiates these different choices by recruiting either specialised or shared neural circuitry remains debated. Specifically, domain-general accounts of prefrontal cortex (PFC) function propose that prefrontal areas flexibly process either perceptual or value-based evidence depending on what is required for the present choice, whereas domain-specific theories posit that PFC sub-areas, such as the left superior frontal sulcus (SFS), selectively integrate evidence relevant for perceptual decisions. Here, we comprehensively test the fu

SUBMITTER: Barretto-Garcia M 

PROVIDER: S-EPMC12858167 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature