Temporal Dynamics and Bidirectional Longitudinal Association Between Physical Function and Depressive Symptoms in Older Adults.

ABSTRACT:

Background

Physical function decline and depression are major challenges of the rapidly growing older population. This longitudinal study aimed to investigate the bidirectional longitudinal association between physical function and depressive symptoms, which are poorly understood in older adults.

Methods

We utilised data from the ASPirin in Reducing Events in the Elderly (ASPREE) clinical trial and extended follow-up cohort between 2010 and 2022. The presence of depressive symptoms was defined as a score of ≥ 8 on the Center for Epidemiologic Studies Depression 10-item scale. Physical function was assessed using gait speed for physical performance and handgrip strength for muscle strength. Gait speed and handgrip strength were categorised using the European Working Group on

SUBMITTER: Mengist B 

PROVIDER: S-EPMC12858256 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature