Nuclear myosin VI cooperates with actin to promote transcriptional cluster formation at androgen receptors.

ABSTRACT: Steroid hormone receptors are ligand-binding transcription factors essential for mammalian physiology. The androgen receptor (AR) binds testosterone mediating gene expression for sexual, somatic, and behavioral functions and is involved in various conditions, including androgen insensitivity syndrome and prostate cancer. Our previous work revealed the actin-dependent formation of transcriptional hubs consisting of the AR, the mammalian formin disheveled-associated activator of morphogenesis 2 (DAAM2) and active RNA Polymerase II (RNA Pol-II). Of note, highly dynamic nuclear F-actin polymerization by DAAM2, directly at the AR is essential for androgen signaling. To better understand actin-driven AR transcriptional activity, we turned our interest to the unconventional myosin VI, which was p

SUBMITTER: Jayawardana IM 

PROVIDER: S-EPMC12858346 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature