Tamoxifen metabolites acting via BK_Ca orchestrate the dynamics of K⁺ and Ca²⁺ in breast cancer cells.

ABSTRACT: The voltage- and calcium (Ca²⁺)-activated potassium (K⁺) channel of large conductance (BK_Ca) is aberrantly expressed in various breast cancer (BC) subtypes, including estrogen receptor (ER)-positive tumors. Increased proliferation of BC cells in response to tamoxifen (TAM) and its metabolites (TAM+M) has been shown to rely on the cell's BK_Ca status. However, the mechanism by which TAM+M impact on BK_Ca activity to promote malignancy is yet not clear. By examining murine MMTV-PyMT tumor-derived BC cells and human BC cell lines with a genetically encoded K⁺ ion indicator and electrophysiological recordings, we identified BK_Ca-dependent intracellular K⁺ signals and currents provoked by treatment with clinic

SUBMITTER: Maier S 

PROVIDER: S-EPMC12858349 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature