Sex-specific acceleration of Alzheimer's pathogenesis by chronic sleep-deprivation.

ABSTRACT:

Introduction

Sleep impairments likely contribute to Alzheimer's pathology, though specific contributions to disease progression are incompletely understood. We propose that autophagic impairment is associated with chronic sleep disruption and examine how sleep loss and stress influence disease development, including having impacts on proteostasis, cognition, and neural circuitry.

Methods

We sleep-disrupted 6-month-old APP^NL-G-F mice for 2 weeks and behaviorally assessed sleep recovery, nesting, stress, and cognition. Subsequently, we analyzed markers of Alzheimer's pathology, stress, neuroinflammation, and proteostasis in hippocampal and subcortical brain regions.

Results

Sleep-deprived mice had altered sleep-related behaviors, increased stress, and signs o

SUBMITTER: Wear D 

PROVIDER: S-EPMC12858427 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature