Analyzing the expression of hsa-miR-661 in peripheral blood mononuclear cells of patients with primary Sjogren's syndrome and its clinical significance.

ABSTRACT:

Objective

This study aimed to assess the expression and clinical significance of hsa-miR-661 in peripheral blood mononuclear cells (PBMCs) of patients with primary Sjögren's syndrome (pSS) and to explore the role of the hsa_circ_0008301/hsa-miR-661/TOLLIP axis in disease progression.

Methods

A total of 58 pSS patients and 58 age- and sex-matched healthy controls, recruited from the General Hospital of Ningxia Medical University between September 2021 and September 2022, were included. Clinical and laboratory data were collected. Hsa-miR-661 expression in PBMCs was measured using quantitative real-time PCR (qRT-PCR). The interaction between hsa_circ_0008301, hsa-miR-661, and TOLLIP was validated using dual-luciferase reporter assays. Group differences were analyzed using t-te

SUBMITTER: Zhang X 

PROVIDER: S-EPMC12858450 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature