Highly enantioselective reduction of benzophenones by engineered Geotrichum candidum alcohol dehydrogenase.

ABSTRACT: Biocatalytic approaches have gained increasing attention as sustainable alternatives to metal-catalyzed asymmetric reductions of ketones to obtain enantiopure alcohols, important intermediates for pharmaceutical synthesis. For example, enzyme-catalyzed reduction of substituted benzophenone analogs to produce chiral diaryl methanols has attracted interest, as they are the key intermediates in the synthesis of antihistamines. However, benzophenone analogs are difficult to be reduced by enzymes due to steric hindrance. Moreover, the similarities between the two groups adjacent to the carbonyl group make achieving high enantioselectivity in reduction challenging. In this study, we examined the reduction of benzophenone and its analogs by Geotrichum candidum acetophenone reductase (GcAPRD). How

SUBMITTER: Tang Z 

PROVIDER: S-EPMC12858457 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature