Association between systemic inflammatory response index and cardiovascular disease risk in rheumatoid arthritis patients: a machine learning based on US and Chinese cohorts.

ABSTRACT:

Background

A high incidence of cardiovascular disease (CVD) is observed among patients with rheumatoid arthritis (RA); although the systemic inflammatory response index (SIRI) has demonstrated predictive utility across inflammatory and cardiovascular disorders, its relationship with CVD risk in RA remains underinvestigated.

Methods

The present study was partitioned into a training set, a temporal validation set, and an external validation set derived from the NHANES database and a Chinese clinical cohort. Between-group differences were characterized, and multivariable logistic regression models were fitted across SIRI tertiles within each dataset. Restricted cubic spline functions were plotted to visualize dose-response associations, and receiver operating characteristic ana

SUBMITTER: Zhang P 

PROVIDER: S-EPMC12858464 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature