Evaluation of blood impurity removal efficiency using the QuEChERS method.

ABSTRACT:

Purpose

Comparison of the impurity removal efficiencies of the deproteinization and Quick, Easy, Cheap, Effective, Rugged, Safe (QuEChERS) methods, which are pretreatment methods for drug analysis adopted by many forensic autopsy institutions, was performed.

Method

Residual cardiac blood samples were pretreated using deproteinization and QuEChERS methods. The residual amounts of total proteins, total lipids, glucose, galactose, electrolytes, and inorganic elements were measured. We also compared the recovery rates and matrix factors when using liquid chromatography/tandem mass spectrometry (LC/MS/MS).

Results

The residual rates of total proteins, total lipids, glucose, galactose, and electrolytes using the deproteinization method were 16%, 75%, 75%, 90%, and 91%, resp

SUBMITTER: Kuze H 

PROVIDER: S-EPMC12858495 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature