Gout flares, serum urate and seasonality: a descriptive cohort study.

ABSTRACT:

Aims

To investigate the relationship between serum urate levels and gout flares and how these vary at different times of the year.

Methods

A cohort of people with incident gout was established using a large UK primary care database (Clinical Practice Research Database). Clinician-recorded gout flares and serum urate (SU) measurements were identified and described using joinpoint linear regression modelling. The relationship between SU level, flare frequency, month of the year and mean monthly temperatures was explored and correlations tested using Pearson correlation coefficients.

Results

249,157 individuals (mean follow-up 6.7 years) experienced 417,101 flares and had 341,457 SU measurements (mean SU 437 µmol/L, standard deviation (SD) 106 µmol/L). SU levels peaked t

SUBMITTER: Finnikin S 

PROVIDER: S-EPMC12858545 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature