Programmed death-ligand 1 (PD-L1) Modulates Chemokine Production Via the TLR4/TRAF6 Signaling Axis During LPS + IFN-γ-Induced Endotoxemia-mimicked Sepsis.

ABSTRACT: As a pivotal immune checkpoint molecule, programmed death-ligand 1 (PD-L1) is anchored primarily on the membrane surface of immune cells, where it exerts immunosuppressive effects, thereby facilitating tumor immune evasion. Macrophages, which serve as essential sentinels of the innate immune system, play dual regulatory roles in inflammatory pathologies, particularly during sepsis progression. While their secreted chemokines mediate inflammatory cell recruitment for pathogen clearance, excessive chemokine production can paradoxically induce organ damage and immune cell exhaustion, necessitating precise regulatory mechanisms. Conventional understanding suggests that PD-L1 on macrophages engages with programmed cell death protein 1 (PD-1) on T lymphocytes to suppress T-cell proliferation, cy

SUBMITTER: Yuan M 

PROVIDER: S-EPMC12858551 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature