SUMOylation machinery protein, PIAS4 role in breast cancer cell proliferation and drug sensitivity.

ABSTRACT:

Purpose

Breast cancer is a significant global health issue, with resistance to doxorubicin (DOX) posing a major challenge to effective treatment. SUMOylation, a post-translational modification process, is linked to cancer progression and therapy resistance. PIAS4, a SUMO E3 ligase involved in maintaining genome stability and stress response, may play a role in these mechanisms. However, its function in breast cancer progression and DOX resistance remains uncertain. This study investigates the potential role of PIAS4 in mediating DOX resistance in breast cancer.

Methods and results

Naked mole-rats (NMRs) are cancer-resistant rodents with improved genome maintenance, yet the role of SUMOylation in this trait remains unclear. SUMOylation machinery gene expression levels are inv

SUBMITTER: Salih MAM 

PROVIDER: S-EPMC12858598 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature