Functional characterisation of Target of Rapamycin (TOR) signalling in Physcomitrella.

ABSTRACT:

Key message

The evolutionary conserved TOR kinase positively controls growth and development of the moss Physcomitrella, development and function of its chloroplasts, its protein synthesis, and cell-cycle progression. Target of Rapamycin (TOR) is a conserved protein kinase and an important signalling hub in eukaryotes. The moss Physcomitrella (Physcomitrium patens) is a model organism for plant physiology, development, and evolution. However, little is known about TOR signalling in non-vascular plants, including Physcomitrella. Here, we report the effects of inhibiting TOR signalling in Physcomitrella. We identified and characterised Physcomitrella 12-kDa FK506-binding protein (FKBP12), which binds TOR in the presence of rapamycin. Whereas the growth of wild-type protonema is unaff

SUBMITTER: Saliba E 

PROVIDER: S-EPMC12858634 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature