Operationalizing the Global Leadership Initiative in Sarcopenia: Muscle-Specific Strength, Optimal Criteria and Clinical Relevance.

ABSTRACT:

Background

While the Global Leadership Initiative on Sarcopenia (GLIS) is promising to standardize sarcopenia diagnosis, its operational implementation remains largely undefined. This study aims to operationalize GLIS and evaluate its feasibility, diagnostic concordance and clinical relevance.

Methods

This three-stage, multicenter study enrolled 12 116 participants for cut-off development (mean age 58.7 years, 48.2% men) and 11 241 participants for outcome analysis (mean age 58.4 years, 49.4% men) from a national survey in China. Another 504 patients with chronic kidney disease were included for validation. We proposed the lower limb skeletal muscle mass to five-time chair stand test ratio (LFR) to assess muscle-specific strength (MSS). The GLIS conceptual framework was inst

SUBMITTER: Yin L 

PROVIDER: S-EPMC12858665 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature