Outcomes and prognostic markers in locally advanced head and neck squamous cell carcinoma underwent chemoradiotherapy.

ABSTRACT:

Background

Head and neck squamous cell carcinoma (HNSCC) has poor survival outcomes, particularly in locally advanced stages. Identifying prognostic factors can help personalize treatment and improve outcomes.

Method

We retrospectively analyzed stage III-IVA/B HNSCC patients who received definitive or adjuvant CRT from January 2015 to January 2024. Demographic, clinical, and laboratory data were collected.

Results

The study included 138 patients. A total of 84 patients received CRT for the definitive aim, while 55 patients received it for the adjuvant aim. The median event free survival (EFS) was 7.65 years (95%CI 6.14-9.15). Factors associated with poor EFS in multivariate analysis were stage IVA/B disease (HR 2.58, 95%CI 1.21-5.49), being underweight (HR 3.54, 95%CI

SUBMITTER: Bolek H 

PROVIDER: S-EPMC12858672 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature