High resolution genome-wide SNP array analyses on matched colorectal-based lung and brain metastases.

ABSTRACT:

Purpose

Colorectal-based brain metastasis formation is a rare and late event in colorectal cancer (CRC) patients and is associated with poor survival. Compared with other metastatic sites, the knowledge about copy number variation (CNV) in brain metastases is still very limited. To get more information about CNVs, we applied SNP array to analyze chromosomal regions with a higher density of SNP markers.

Methods

Genome-wide high resolution single nucleotide polymorphism (SNP) array (CytoScan™ HD) analyses were carried out in matched colorectal-based lung and brain metastases of two patients.

Results

Brain metastases harbored more CNVs (77 CNVs) than pulmonary metastases (24 CNVs). Not previously described specific CNVs were: gain of 1p36.33-p36.32, 4p16.3-p16.1, 6q27, 1

SUBMITTER: Brandt VP 

PROVIDER: S-EPMC12858677 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature