PRC1 promotes immunosuppressive macrophages in sepsis via β-catenin/STAT3 signaling.

ABSTRACT:

Background

Immunosuppression is a distinctive condition resulting from sepsis, marked by impaired immune response and immune dysregulation, with a poor prognosis. PRC1, a mitotic regulatory protein, is associated with immune suppression within the tumor microenvironment. However, the role of PRC1 in septic immunosuppression remains unclear. This research aimed to explore the implication and potential mechanism of PRC1 in septic immunosuppression.

Methods

Dataset GSE95233 and GSE65682 were used to validate the expression and prognostic value of PRC1 in sepsis patients. LPS was used to stimulate naïve or endotoxin-tolerant THP-1 and BMDMs. PRC1 expression was measured in by RT-qPCR and Western blot. Small interfering RNA was used for PRC1 knockdown in THP-1. The phosphorylated

SUBMITTER: Zuo Y 

PROVIDER: S-EPMC12858680 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature