Establishment and validation of a clinical threshold criteria for choosing PET imaging tracers for indolent non-Hodgkin's lymphoma.

ABSTRACT:

Background

[¹⁸F]FDG PET-CT scan has a lower sensitivity in imaging of indolent non-Hodgkin's Lymphoma (NHL.) We aimed at identifying a threshold of clinical/pathological indicators which would independently predict [¹⁸F]FDG PET-CT scan positivity. For this purpose, we used a retrospective real-world cohort of NHL patients and then validated this criterion on [¹⁸F]FDG and [⁶⁸Ga]Pentixafor scans in a prospective indolent NHL cohort.

Results

In the retrospective real-world cohort of NHL, Ki67 was identified as an independent factor that influenced [¹⁸F]FDG uptake (r = 0.701). The cutoff value for Ki67 was 36.5% with a maximum area under the curve (AUC) of 0.811 and a Youden index of 0.494 for predicting [¹⁸F]FDG

SUBMITTER: Yu X 

PROVIDER: S-EPMC12858696 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature