Causal Associations Between Human Blood Metabolites and Cardio-Cerebrovascular Diseases: A Mendelian Randomisation Study.

ABSTRACT: BackgroundBlood metabolites are crucial in various aspects of human health. However, current evidence regarding the role of circulating metabolites in various cardio-cerebrovascular diseases (CVDs) is limited. Mendelian randomisation (MR) can be used to provide information about these metabolites.ObjectivesOur primary aim was to investigate the causal relations between human blood metabolites and the risk of 10 CVDs.MethodsWe conducted a two-sample MR study. Data on 486 human blood metabolites were obtained from a genome-wide association study (GWAS) involving 7824 participants. Outcome data were sourced from the most recent large-scale GWAS meta-analysis by FinnGen (R9) on various CVDs. The inverse variance-weighted (IVW) model was used as the primary method for this analysis. Moreover, w

SUBMITTER: Zhang H 

PROVIDER: S-EPMC12858759 | biostudies-literature | 2026 Jan-Dec

REPOSITORIES: biostudies-literature